Raheleh Ravanfar
Ball State University, USA
Title: Optimization of solid lipid nanoparticles prepared by microemulsion dilution for microencapsulation of bioactive compounds from red cabbage
Biography
Biography: Raheleh Ravanfar
Abstract
Anthocyanins are the main polyphenol components in extract of fresh red cabbage (Brassica oleracea) with inherent anti-oxidant activity. To protect them against harsh environmental conditions (e.g. pH and temperature), solid lipid nanoparticles were prepared by dilution of w/o microemulsion containing anthocyanins, in aqueous media. The formulations were characterized regarding particle size and encapsulation efficiency. The formulation parameters (e.g. % total lipid, volume of internal aqueous phase, homogenization time, % total surfactant, % stabilizer) were optimized by Placket-Burman and Box-Behnken experimental designs. The highest value of EE (89%) was obtained when mean particle size was 6 microns and the lowest particle size (417 nm) was achieved while EE value was 35.8%. SEM study revealed a spherical morphology of the particles.