Sue Hudson Duran
Auburn University, USA
Title: Development of sustained release antifungal, anti-protozoa and antimicrobial products in horses using hydrogels and extended release formulations in veterinary medicine
Biography
Biography: Sue Hudson Duran
Abstract
Therapies and compliance of treatment in horses and cattle are a challenge for veterinarians and owners. The goal of our research team is to develop new antifungals and antimicrobials using appropriate hydrogels and other delivery systems. Voriconazole-hydrogel has been studied in an in-vitro model using the Franz Cell diffusion apparatus and cadaver horse eye tissues. Drug levels in the cornea and sclera were measured. Formulations release the drug for up to 28 days above the minimum inhibitory concentration needed to treat most fungal eye infections. The next step is testing the product in horses. Other formulations that have been studies for efficacy and release time include gentamicin, vancomycin and amikacin-impgregnated calcium sulfate and polymethylmetacrylate (PMMA) beads for successful treatment of osteomyelitis in dogs and horses and topicaly antiprotozoal drugs in cattle for Trichomonas. Indeed, successful alternatives are needed for ease of treatment in animals.