Jim Jingjun Huang
Ascendia Pharmaceuticals, USA
Title: Parenteral drug delivery systems for insoluble drugs
Biography
Biography: Jim Jingjun Huang
Abstract
Poor water solubility of more than 60-80% of new chemical entity present a major hurdles in the design of suitable drug delivery systems for the market dosage form. Administration of those compounds by parenteral route without causing injection site reaction and systemic toxicity effects constitutes another barrier. Current solubilization and parenteral delivery technologies for water insoluble drug are summarized. The key considerations in design of stable parenteral drug delivery system, such as drug physico-chemical and biopharmaceutical properties, selection and evaluation of solubilization and delivery technology, and excipients are presented. Case studies in development of nanoemulsions and nanosuspension are presented.