Asmita Gajbhiye
Dr. Hari Singh Gour Central University, India
Title: Bioavailability enhancement of flavonoids through vesicular complex with soya phosphatidylcholine
Biography
Biography: Asmita Gajbhiye
Abstract
Quercetin, mangifirin, kaempferol are a well-known flavonoidal compounds found in plants, foods, and beverages. These flavonoids have shown several pharmacological activities including antioxidant, anti-inflammatory, anticancer, and antiviral properties. In spite of a variety of biological effects, they are very poorly soluble in water, which has limited their absorption upon oral administration and rapid clearance from intestine. Therefore, it is required to develop a drug delivery system to resolve this problem.
Some phytoconstituents that are not effectively bioavailable, by binding them to phosphatidylcholine, they can be made in highly bioavailable form. One of the most important group of phytoconstituents is the flavonoid which can be bind with soya phosphatidylcholine (SPC). The resulting phytosomes formed are protected from distruction by digestive secretions and gut bacteria. The phytosomes intensifies herbal compounds by improving absorption, increasing bioavailablility and enhancing therapeutic potential. The phytosomes contains active ingredients of herb surrounded and chemically bound with phosphatidylcholine which is one of the chief components of the membranes in the human cells.
Phytosomes of Quercetin, mangifirin and kaempferol were successfully prepared through complexation with soya phosphatidylcholine (SPC) which were characterized by spectroscopic (IR and NMR), microscopic (TEM) and colorimetric (DSC) analysis. The pharmacokinetic study was performed for the assessment of bioavailability.
The IR, NMR and DSC spectra of phytosomes were showed by different peaks as compared to that of phytosomes. Pharmacokinetic study revealed significant increased absorption of phytosomes.
The prepared complexes were characterized by solubility studies, DSC, TLC, FTIR and 1H-NMR spectroscopic analysis. These physicochemical and spectroscopic investigations clearly showed evidence for the formation of quercetin–soya phosphatidylcholine complex.
The result of pharmacokinetic study clearly indicates that vesicular complex is more easily absorb than individual ingredients and hence it can be concluded that drug-SPC complex is more bioavaliable than individual ingredients.