Rana Mhd Farid Sammour
Dubai Pharmacy College, UAE
Title: Optimization of Aceclofenac proniosomes by using mannitol as a carrier
Biography
Biography: Rana Mhd Farid Sammour
Abstract
Aim is to optimize a free-flowing and stable proniosome formulation of Aceclofenac that is considered as a poorly water-soluble drug by using mannitol as a carrier. Slurry method were used for the preparation of the proniosomes by using span60, cholesterol, mannitol and Aceclofenac as a drug. Different characterization were done for the prepared proniosomes such as DSC, FTIR and flowability. While Entrapment Efficiency and Zetapotential with Zetasizer were done for the niosomes derived from Aceclofenac proniosomes after hydration. In vitro drug released were studied by using the diffusion membrane technique and percentage of drug release were analyzed by using HPLC method. The proniosomal powder were compatible and exhibited excellent flowability. The niosomes derived from