10th World Congress on Bioavailability & Bioequivalence
Dubai Pharmacy College, UAE
Title: The effect of mucoadhesive polymers in improving drug bioavailability & absorption
Biography: Amal Ahmed Abdel Nabbi Hassan
The oral mucosa offers an interesting site for the application of dosage forms that release drugs within/throughout the oral mucosa, by assuring a high drug bioavailability for topic and systemic effects. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. In addition to factors related to the oral mucosa and oral environment features, the physical-chemical characteristics of mucoadhesive polymers must be also considered as factors influencing the mucoadhesive bonds
The study was conducted to formulate different types of MDDS, using mucoadhesive polymers (e.g. carbopols, sodium alginate, chitosan…) and have been utilized in different dosage forms in efforts to achieve systemic delivery of drugs through mucosal membrane.
Conclusion: Since a sustained drug release can be guaranteed only if dosage forms remain in contact with the oral site of absorption/application for a prolonged time, the development of mucoadhesive dosage forms is mandatory. They can prolong the residence time of the dosage form at the site of absorption thus enhance drug therapeutic efficacy.