Bioavailability & Bioequivalence: Pharmaceutical R & D Summit

Palmer Taylor, Ph.D. holds the Sandra & Monroe Trout Chair of Pharmacology at the University of California, San Diego.  He served as Founding Dean of the Skaggs School of Pharmacy & Pharmaceutical Sciences (2002-2014) and previously as Chair of the Department of Pharmacology in the School of School of Medicine (1987-2002).  His research is directed to molecular pharmacology and neurotransmission, through study of the structures and functions of acetylcholinesterase (AChE) and nicotinic acetylcholine receptors (nAChRs).  Of particular interest are molecular recognition and design of selective therapeutic agents, directed to the nAChR subtype and to antidotes that reactivate of organophosphate-conjugated AChE.  The soluble acetylcholine binding protein has been the template for design of agonists and antagonists of the AChR subtype potentially useful in treatment of disorders of nervous system development and aging.  His group has also been responsible for development of small zwitterion antidotes that serve as reactivators for organophosphate poisoning.