Bioavailability

A drug's total bioavailability is typically less than one when administered via an extravascular route. A variety of physiological factors reduce the availability of medicines before they enter the systemic circulation. Absorption will be affected whether the medication is taken with or without food. Other medications taken concurrently may alter absorption and first-pass metabolism, intestinal motility may alter how the medication is terminated, and intestinal micro flora may influence how much of the medication is chemically humiliated. There will also be a conclusion regarding conditions that impair the digestive system or the liver's function..

  • Hepatic first-pass effect
  • Factors affecting bioavailability
  • Route of administration
  • Relative bioavailability
  • Absolute bioavailability

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