Drug Metabolism

It is accustomed specific the biotransformation of pharmaceutical substances within the body. so they will be terminate additional merely. The mass of metabolic processes that needed medication takes place within the liver, because the enzymes that facilitate the reactions square measure reduced. Most medication should flow through the liver; this is often the first web site of drug metabolism. Once within the liver, enzymes transforms prod rugs into active metabolites and convert active medication into inactive forms

 

  • Phase 1 metabolism of drug: P450 (CYP450)Enzyme
  • Phase I vs. Phase II Metabolism
  • Food/herbal remedies- drug interaction
  • Drug Efficacy and toxicity
  • Plasma Concentrations and Drug Effects

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