Bioavailability and Bioequivalence

Food-Drug Interactions in Bioequivalence

Food-drug interactions can significantly impact drug absorption and bioequivalence assessments. Food intake can alter gastric pH, transit time, and enzyme activity, affecting drug dissolution and absorption rates. Consequently, bioavailability may vary between fed and fasting states, leading to potential discrepancies in bioequivalence study results. Understanding and controlling these interactions are crucial to ensure the reliability and reproducibility of bioequivalence data for regulatory approval of generic medication.