In Vitro-In Vivo Correlation

IVIVC, or In Vitro-In Vivo Correlation, is a scientific approach used in pharmaceutical development to establish a relationship between in vitro drug release profiles and in vivo pharmacokinetic behavior. By correlating the performance of a drug product in vitro with its behavior in vivo, IVIVC can provide insights into the factors influencing drug absorption and predict in vivo performance based on in vitro data. This correlation aids in formulation optimization, dosage form selection, and biowaiver justifications, ultimately streamlining the drug development process. IVIVC is particularly valuable in ensuring consistent drug release and bioavailability, enhancing the efficiency and cost-effectiveness of drug development efforts.

 

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